Molecular imaging methods are playing an increasingly significant role in drug development, creating a need for versatile and efficient methodology to introduce appropriate radiolabels.  Ekam provides clients with custom chemical synthesis and radio-labeling for both the development of biomarkers for disease diagnosis and prospective studies on drug efficacy. Such capabilities include, but are not limited to:

• Expeditious synthetic procedures (less than 10 minute reaction times) that extend useable half-lives of radionuclides
• Direct installation of radiochemically functionalized aliphatic chains of varying length (including new molecular entities)
• Re-purposing molecules using different labels and add-ons
• Products free of toxic by-products and metals
• Highly efficient post-labeling clean up procedures
• Automation of the production process (e.g., flow compatible) with increased yields and lower costs
• Backwards compatibility with late state drug intermediates using Pd catalyzed reactions (Negishi, Sonogashira, Hiyama, Heck)
• Conversion of aryl iodides to fluorides (repurposing of SPECT ligands for PET)
• The labeling of proteins and antibodies